Kaspersky 2009(V8) which is a TR at the moment and should be released sometime in June has been getting rave reviews, they have added new tools, but the footprint is smaller.
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Major Improvements in v8:
-NEW...HIPS
-NEW...Whitelisting Technology (whitelisting certain programs to automatically allow Kaspersky to decide whether an application can connect to the internet and perform specific activity... less user intervention and more user friendly... less popups and requests from PDM and firewall.
-NEW...Scanning of Vulnerabilities in installed programs (so you can update them to prevent the programs being "exploited" and malware being installed on your computer via them)
-NEW...Advanced Reporting Capabilities (more in depth reports of activity of your programs and more statistics)
-NEW...Virtual Keyboard (to prevent keyloggets logging keys, good to use when entering personal details/passwords)
-NEW...Database of malicious URLs (Alerting users about prolific malware hosting websites)
-NEW...System Restore Wizard (Help fix damage caused to the computer after an infection; restoring functionality)
-NEW...GUI
-IMPROVED...Speed of overall product components (More efficient and faster scanning and will not slow computer down as much as previous versions thanks to the rebuilt/improved antivirus engine.
Other Improvements:
-Enhanced PDM
-Improved Heuristics
-New Packer Detection (suspicious packer and multi-packer)
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ScreenShots:
http://malwarecrawler.com/kaspersky/